Type 2 diabetes occurs when the pancreas cannot secrete enough insulin, usually under conditions of chronic overconsumption of fuel, inactivity, overweight, and insulin resistance.
Some people are more susceptible to developing diabetes than others. If your body sends excess fuel to develop fat in the abdomen around organs like the heart, pancreas, and in and around the liver then you are more likely to develop diabetes than someone who stores excess fuel under the skin.
Genes play a role in diabetes; studies have shown that if family members are affected then your risk for developing diabetes is increased. More than 40 genes associated with diabetes have been identified.
Type 2 diabetes is on the rise around the world. Some of the factors that have led to this increase include: consumption of excess food, a high sugar, high fat, low fiber diet, an increase in sedentary lifestyle, deficiencies in vitamin D and B12, and exposure to chemical pollutants (pesticides and plasticizers). In addition, poverty, depression, and sleep deprivation may all contribute to risk for diabetes.
When high sugar, high fat foods are over-consumed, the body’s system of energy balance and appetite control is affected. In people who are susceptible to diabetes, excess fuel damages the islet beta cells (which produce insulin) and damage occurs to fat cells, which cannot properly store the excess fuel. As a result, the fuel spills over into the blood and other areas of the body, such as the liver and muscles. This nutrient spillover also means that molecules called inflammatory cytokines are released into the blood and cause stress and injury to various internal organs.
|Gene||a segment of DNA that provides coded instructions for proteins. Gene function is complicated, for more info go to http://tinyurl.com/3c9gqro|
|Insulin||a hormone that helps the body store or use glucose for energy|
|Insulin resistance||muscle, fat and liver cells do not respond properly to insulin|
|Islet beta cells||the cells in the pancreas that produce insulin|
|Metabolic stress||stress to the body’s cells from nutrient excess|
|Pancreas||an organ in the abdomen that secretes hormones and chemicals to aid digestion of food|
|Pre-diabetes||a condition where blood glucose levels are higher than normal, but not yet high enough for a diagnosis of diabetes|
|Inflammatory cytokines||molecules that signal cells|